Wesam Osama Hassan, Geraldine Mohamed Ahmed, Olfat Gamil Shaker And Shamiaa Ismail Gawdat,

ABSTRACT


Aim: The Aim Of This Prospective, Randomized, Single-blind, Clinical Trial Was To Evaluate The Effect Of Combination Of Calcium Hydroxide Paste With 2 % Chlorhexidine Gel As Intracanal Medication In Comparison With Calcium Hydroxide Paste Alone On Post-operative Pain At 4, 24, 48 Hours And 14 Days After The First Visit And Its Effect On Bacterial Endotoxins In Teeth With Necrotic Pulp. Methods: Forty Five Patients Aged 15-66 Years With Single Rooted Tooth With Necrotic Pulp Were Subjected To Conventional Root Canal Treatment In Two Visits. All Patients Were Divided By Randomization Into 3 Groups, Each Group Contained 15 Patients (n=15). Group A Was Subjected To Calcium Hydroxide Combined With 2% Chlorhexidine Gel For Two Weeks; Group B Was Subjected To Calcium Hydroxide Paste For Two Weeks, While Group C Was Subjected To No Intracanal Medication For Also Two Weeks. Post-operative Pain Was Assessed By Using Numerical Pain Rating Scale (NRS) At 4, 24, 48 Hours And 14 Days After The First Visit, While Endotoxin Assessment Was Performed By Limulus Amebocyte Lysate Test By Taking Samples From The Root Canal After Access Cavity Preparation (S1), After Chemo-mechanical Preparation (S2) Before The Application Of The Intracanal Medications And After 14 Days Before The Obturation (S3).

Results: There Was No Significant Difference Between The Three Groups Regarding The Main Demographic Data Including: Age, Gender And Tooth Type (p>0.05). ). Results Showed No Significant Difference Between The Three Groups Regarding Post-operative Pain Incidence After 4, 24, 48 Hours And 14 Days Postoperatively (p>0.05). Regarding Endotoxin, Results Showed That There Was Significant Difference Between The Three Groups At S1, S2 And S3 (p<0.05). Conclusion: The Application Of Calcium Hydroxide Combined With 2 % Chlorhexidine Gel, Calcium Hydroxide Or Without The Application Of Intracanal Medicaments Didn?t Seem To Affect On Postoperative Pain At 4, 24, 48 Hours And 14 Days, While Its Application Has An Effect On Endotoxin Concentration In Teeth With Necrotic Pulp.